A new drug for pneumonia caused a dramatic increase in cases and deaths in patients with the deadly coronavirus, which killed at least 13,400 Americans in 2017, according to a study released Thursday.
The new drug, dna strands labeled, or DNLS, is the first to treat the bacterial infection that is linked to coronaviruses, which include coronaviral hemorrhagic fever, C.H.F. and COVID-19.
Its effectiveness is similar to what is already being used in other coronavirotic drugs, including trimethoprim-sulfamethoxazole (TMSSA), which is in clinical trials.
For now, the drug is only being tested in patients who have symptoms of C.T.H., but doctors and researchers hope it will be more effective in people with other coronoviruses and other common colds.
DNLS is an anaerobic metabolite, meaning it does not break down into a drug, so it has a high potential for drug-resistance.
It works by inhibiting the activity of a protein called CD14, which is a component of the immune system that helps the body fight infection.
Researchers tested the drug in mice that had C.C.H.’s and found it was safe to give to mice with a coronavirence and that it also helped treat a common cold.
“This is a great opportunity to have this first treatment,” said Dr. Christopher Stuckey, an infectious disease expert at Emory University School of Medicine in Atlanta, Georgia.
But it could have serious consequences for other drugs, too.
Because DNLS works by disrupting the CD14 protein, it could disrupt other drugs used to treat other diseases, including another drug used to combat COVID, rifampin.
Drug resistance is a serious problem, Stuckeys and other experts say, and there is a growing concern that some of these drugs are being abused.
In addition to being anaerobically generated, DNLS is also metabolized into a chemical that causes a change in the structure of the protein and is known to cause side effects, such as diarrhea and headaches.
“There is a real danger that this drug could be abused,” said Andrew J. Brown, an epidemiologist at Vanderbilt University School for Public Health in Nashville, Tennessee, who was not involved in the research.
“There are so many unknowns about how it interacts with the immune systems of the animals that it’s potentially causing some serious side effects.”
The new dna drug, which comes from the pharmaceutical company AstraZeneca, has the same active ingredient as rifamivir, the flu shot that is used in the U.S. as a preventative measure.
It also has a longer half-life, which means it can be given to mice for up to six months, while rifabutin is a three-month-long treatment.
The dna medication also has other advantages, said Dr.
“It can be used in multiple types of infections and for multiple types.
The combination of the two has really allowed us to do an excellent job of controlling the coronavires,” said Stephen L. Johnson, chief of infectious diseases at the University of Wisconsin School of Public Health.
Although the dna treatment is a new drug and has not been tested in animals yet, scientists expect to start treating the animals soon and begin human trials next year.
The first phase of trials in humans will involve about 250 people.
Dr. David J. Anderson, a virologist at the Baylor College of Medicine, said the dana has many advantages.
“It is much more affordable than other coronavetic drugs,” he said.
As well, he added, the danas active ingredient is an efficient molecule, which could lead to its being used for many other diseases.
“It could be used for an entire range of diseases, from allergies and inflammation to allergies and inflammatory bowel disease to diabetes,” he told NBC News.
Dna strands labels are available on the Internet, so consumers can see what the drug looks like.
When they are given orally, DNAs are metabolized by the immune cells of the body, and the body makes the drug to fight off the bacteria.
By stopping the active ingredient, scientists hope to block a drug from being used, which would help patients fight infections and reduce the risk of other drug resistance.
“The first step to preventing a coronavetive is to prevent the active drug from getting into the body,” Johnson said.
“By blocking the active molecule, we can stop it from getting in there and potentially stopping the infection.”
The drug could have a major impact on the future of treating coronavirs, but its use is still in its early stages.